Estudio de la eficacia de sellado en el periodo interdialítico largo para catéteres de hemodiálisis disfuncionantes

Abstract

The sealing of the tunneled venous catheters with different solutions has been used both in prevention and in the treatment of complications, however, there is no ideal solution. The aim of the study is to compare the complications of dysfunctional catheters with different weekend sealing patterns, Urokinase 10,000 IU vs TauroLock™ -U25,000, as well as dialytic efficacy of both substances. A longitudinal observational cohort study in which the cases of infection, thrombosis and functionality of the tunneled catheter were analyzed. Only patients with a dysfunctioning catheter who had previously prescribed a sealing pattern with urokinase in the long interdialytic period were included. The study period was four months; two months sealed with 10,000 IU of Urokinase and the other ones, sealed with TauroLock ™ -U25,000. Urokinase vs Taurolidine averages: blood flow, venous pressure, recirculation, KT (53.3 / 55L), manipulation and extra doses of urokinase were better in the Taurolock period, although no statistically significant differences were found. The mean arterial pressure is close to the significance (p = 0.067), also better in the Taurolock period. There was a difference in the KT mean, favorable to the Taurolock period, which has no statistical significance and is exclusive to patients who did not require extra urokinase. The main limitation of our study is the sample size that may be partly responsible for the absence of statistical significance. Studies with more patients are necessary.